s۱۰۰b protein as a post-traumatic biomarker for prediction of brain death in association with patient outcomes
نویسندگان
چکیده
conclusions changes in s100b protein, especially the levels of this dimer 48 hours after trauma can be used as marker to predict brain death. alongside other known prognostic factors such as age, gcs and diameters of the pupils, however, this factor individually can not conclusive predict the patient's clinical course and incidence of brain death. however, it is suitable to use gcs, ct scan, clinical symptoms and biomarkers together for a perfect prediction of brain death. results primary and the last gcs of patients had a predictive value in determining brain death (p < 0.0005), also there was a significant correlation between gcs and level of s100b protein. there was a significant correlation between ct scan findings and s100b protein only after 48 hours of trauma. background s100b is a calcium-binding protein, belonging to the s100 family proteins which are characterized by their high solubility and, currently, comprises 21 members which are expressed in a cell-specific manner. if we can predict the possibility of definite brain death after brain injury, we will rescue some organs of body to transplant proposes. patients and methods 72 patients (50 male and 22 female) aged 5 - 80 years old (median 40 ± 17.72 years) with severe head traumas (gcs ≤ 8) were recruited in this cross-sectional study. glasgow coma scale (gcs) and computed tomography (ct) scan findings were recorded for all patients, and then a single 5ml blood sample was obtained from each patient on admission, after 48 hours and a week later or after brain death to determine the level of s100b protein. objectives in this regard our study focused on the s100b protein value in predicting brain death after head trauma. in this study, the use of serum level of protein s100, 24 hours after trauma has been considered as a reliable index for predicting brain death.
منابع مشابه
S100B Protein as a Post-traumatic Biomarker for Prediction of Brain Death in Association With Patient Outcomes
BACKGROUND S100B is a calcium-binding protein, belonging to the S100 family proteins which are characterized by their high solubility and, currently, comprises 21 members which are expressed in a cell-specific manner. If we can predict the possibility of definite brain death after brain injury, we will rescue some organs of body to transplant proposes. OBJECTIVES In this regard our study focu...
متن کاملThe probability of indicating Osteoprotegrin as a biomarker for osteoporosis in patient with thalassemia major
Background: Osteoporosis is one of the main causes of morbidity in patients with thalassemia major. Osteoprotegerin (OPG) is secreted by osteoblasts and osteogenic stromal stem cells and protects the skeleton from excessive bone reabsorption. In this study, the authors aimed to assess the relationship between OPG with osteoporosis and osteopenia in patients with thalassemia major. Materials an...
متن کاملEffects of minocycline on neurological outcomes in patients with acute traumatic brain injury: a pilot study
Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...
متن کاملEffects of minocycline on neurological outcomes in patients with acute traumatic brain injury: a pilot study
Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...
متن کاملPrediction of post traumatic growth based on social support, coping styles and optimism in patients with Brain Tumor
Introduction: Brain tumorr is a deadly disease but patients can have positive growth psychologically. It is important to find factors that lead psychological growth of patients. Therefore, this study was aimed to predict the post traumatic growth based on social support, coping styles and optimism in patients with brain tumor. Methods: In this correlational and descriptive study, the statistic...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
archives of trauma researchجلد ۲، شماره ۲، صفحات ۷۶-۸۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023